Potential Coronavirus vaccines head towards crucial third step

The race for a Covid-19 vaccine has taken on critical importance as the disease continues to charge through the global population, with almost 15 million confirmed cases and nearly 615,000 deaths.
The world hopes a vaccine can be a silver bullet out of the crisis, and new results from some of the teams leading development are showing early promising signs. But the real test lies ahead in the final-phase trials, experts say.
The new data out on Monday includes a vaccine candidate produced by a team at Oxford University, working in partnership with British firm AstraZeneca.
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The candidate was safe and induced strong immune responses in combined phase-one and phase-two trials, according to a study published in The Lancet scientific journal.
A candidate from Chinese biopharmaceutical company CanSino Biologics, produced in collaboration with the Chinese military, was also found to be safe and able to create an immune response in most candidates, according to results from phase-two trials, also published in The Lancet on Monday.
A second set of preliminary results for a vaccine candidate produced by United States company Pfizer and German partner BioNTech were released as non-peer-reviewed data on Monday. This candidate also produced a strong antibody response.
While all three candidates created some side effects, none were severe or life-threatening.
Mike Ryan, executive director of the World Health Organisation’s Health Emergencies Programme, welcomed the data release as “good news” in a press briefing on Monday. But he warned that “there is a long way to go” as candidates moved into “real-world, larger phase trials.”
Early-stage trials look to evaluate issues such as the safety, dosing and side effects of a vaccine candidate. They also check for the effectiveness in producing a potentially virus-neutralizing immune response.
Phase-three trials, the last phase before possible regulatory approval, continue to monitor for safety while evaluating how effective a vaccine is at protecting people from getting sick in their daily lives. These trials often aim to include people from diverse demographics and can have sample sizes in the tens of thousands.
Immunologist Kylie Quinn, a vice-chancellor’s research fellow at RMIT University in Australia, said the latest round of results, indicating that candidates were producing the immune response researchers were looking for, marked a “crucial hurdle” on the path towards a vaccine.
“When they can get over that hurdle, then it makes it worthwhile to do a phase-three trial to really test if (the candidates) can work in a general population,” she said.
But tempering expectations is also essential, Quinn said, as approved vaccines might not be able to protect people from the disease completely. But they could still “provide benefits in reducing disease severity and the transmission of the virus from person to person.”
Several phase-three trials are already ongoing or expected to begin this month. Predictions about when potentially approved vaccines could be ready for market range from the end of this year to mid-2021.
Two vaccine candidates produced by Chinese teams are in final-phase trials, with one by Chinese firm, Sinopharm, in trials in Abu Dhabi, and another by Sinovac Biotech’s being the subject of trials in Brazil. CanSino earlier this month said that it was in talks for its overseas phase-three trials.
Low numbers of infections in China have made clinical trials in the country difficult.
The vaccine candidate from Oxford University and AstraZeneca is already in phase-three trials in Brazil and South Africa, with enrolment open in the US for a large-scale test.
US company Moderna, working with the US National Institute of Allergy and Infectious Diseases, plans to start final-phase trials at the end of the month. The team last week published its phase-one results showing its product was safe and produced immune responses.
The Pfizer and BioNTech candidate may also enter late-stage testing this month, pending approval.
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NASCAR Is Bringing Back Underglow at This Year’s All-Star Race: Report

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It wouldn’t be a stretch to assume most of you remember Pimp My Ride, or Need for Speed: Underground. Media like that made underglow neon seem cool (at least on TV), and it was the thing to have if you wanted to get some extra attention at car meets. Well, LEDs have made it a whole lot easier to get into the underglow game, and it seems like NASCAR is finally catching on. For its All-Star Cup race, the organization apparently plans to mount LEDs around the fuel cell on the back of each race car, giving manufacturers their own unique luminescent signature.
We know this because of a post on the NASCAR subreddit, and a thread on Twitter started by auto sleuth extraordinaire Bozi Tatarevic. Tatarevic tells us that while his sources are not within the NASCAR organization itself, they are team employees.


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According to Tatarevic’s sources, different colors will be associated with different brands of cars. Ford will be blue, Chevy will be amber, and Toyota will be red. Since this year’s All-Star race is going to be held at night, the underglow lighting should look pretty sharp. That is if it’s not washed out by the powerful lights already illuminating the track.
And don’t think that these added lights will affect the performance of the cars in any way. NASCAR is using conventional lightweight LED strips, so the total added weight will be less than six ounces, according to Tatarevic. The strips will also be secured every four inches with foil tape so they don’t fly off into another car.
The All-Star Cup race will feature 15 drivers from the Cup Series and last for 140 laps. You can tune in to see this 2000s-era underglow glory at 7 p.m. ET on Wednesday, July 15. Unlike previous All-Star events, this year’s will be held at Bristol Motor Speedway, as opposed to the usual Charlottesville venue. That’s great, because short track racing is usually way more entertaining.
Spectators will be allowed in-person to see the under-glow for themselves; however, the stadium will be at 20 percent capacity to encourage social distancing. That’s still 30,000 seats available for anyone who wants to come and watch, though.
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18-letnia córka Cindy Crawford pozuje nago dla “Vogue’a”. “To jest ikoniczne”


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Danilo Pereira Admits He’s Keen on Premier League Switch Amid Arsenal Interest

Danilo Pereira says he would be a good fit for the Premier League and has described it as ‘the best league in the world’ as he continues to be linked with a move to Arsenal.
The Porto midfielder has been identified as one of Arsenal’s main transfer target this summer -according to a number of report at least – and is confident that his style of play would suit the potential switch.
Speaking to Stats Perform News, Danilo was eager to praise Arsenal head coach Mikel Arteta, stating that so far he’s done a ‘really, really good job’. He also praised Arsenal’s style of play under their new coach and discussed how he could fit in:.
“He is a Spanish coach, he is a bit similar to Portuguese coaches, they also want to play with the ball and improve with the ball, so I think he is a good coach,” Danilo began.
“The style I think I can fit there, the way he plays also thinking on the ball, the team always has to be together – I think it is a good way to play”.
The Portugal international admitted that while he was enjoying his football in Portugal, he has desires to play in the English top-flight, having already played in Serie A.
Danilo spent three years with Parma from 2010 to 2013 after coming through Benfica’s youth system, but returned to Portugal with Maritmo in 2013. He then signed for Porto in 2015 and has impressed this season, with former Arsenal player Abel Xavier even comparing him to Gunners legend Patrick Viera.
The 28-year-old described Viera as an ‘idol’ in the same interview, further fuelling the links to Arsenal. Predominantly a defensive midfielder, Danilo has played 38 times in all competitions this season, but can also drop into centre back. With Arsenal continually linked for fellow defensive midfielder Thomas Partey, a move for Danilo could prove less costly – and he’s clearly keen on a move to north London.
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Cumhurbaşkanı Başdanışmanı Prof. Dr. Aybet:
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